Tested for you: Epigenetic skincare „SkinSpan Advanced Skin Serum“ from Avea

Epigenetics and longevity are the buzzwords in modern skin aging research and thus also in innovative skin care. Most conventional serums still focus on superficial treatment of the skin. They are all about moisturizing and the much-praised instant glow. But that’s not enough for a longevity effect. To achieve a profound effect, the most important factors of skin aging must be addressed. Epigenetic skincare is the magic word.

Based on epigenetics

What is epigenetics? It is the study of heritable changes in gene activity that are not based on changes in the DNA sequence. It acts as an interface between environmental factors and genes by determining which genes are switched on or off through chemical modifications (such as DNA methylation). These reversible mechanisms enable adaptations to the environment, lifestyle, and diet

But don’t worry, Epigentic Skincare is not about genetic intervention or changes to DNA. The science of epigenetics merely provides the inspiration for an innovative skincare strategy that supports the natural functions of skin cells, enabling them to work more efficiently and keeping the skin more resilient in the long term.

SkinSpan Serum targets the root causes of visible skin aging. These are key biological processes such as cellular energy supply, regenerative capacity, the formation of structure-giving proteins, and a stable skin barrier. The serum was developed in collaboration with leading longevity scientists in Switzerland to holistically address the four most important biological triggers of skin aging.

New beauty trend with depth

This innovative serum combines several mechanisms of action that are relevant in current skin aging research: it focuses on supporting mitochondrial energy production, autophagic cleansing, synthetic processes of collagen and elastin, and strengthening the skin barrier.

To achieve these goals, biotechnologically developed extracts and peptides are used, such as a biomimetic peptide that stimulates cellular cleansing processes. Autophagy is an important approach in longevity research and is considered central to healthy cell function. Autophagy refers to a cellular “recycling process” (self-cleaning) in which cells break down damaged components, misfolded proteins, or obsolete organelles to gain energy and form new cell structures.

If this cell-specific waste disposal system no longer functions properly, defective proteins and damaged cell components accumulate. This leads to accelerated cell aging, inflammation, and cell death. This, in turn, increases the risk of neurodegenerative diseases (Alzheimer’s, Parkinson’s), cancer, cardiovascular problems, and diabetes, as the cells lose their function. In addition, the skin ages faster. The result of functioning autophagy, on the other hand, is a smoother texture, improved radiance, and, over time, visibly youthful, more resilient skin.

Furthermore, an active ingredient is used to increase NAD⁺ in order to promote cell energy. Plant stem cell exosomes are used to stimulate the production of collagen and elastin, as these elastic fibers lose density with age. In addition, a complex of niacinamide, ectoine, hyaluronic acid, and other barrier strengtheners is added to reduce transepidermal water loss and support skin firmness.

The “bad” four

Here is an overview of the four key factors in skin aging and how Avea’s longevity research is attempting to counteract them with Skinspan Serum:

• Decline in NAD⁺: RejuveNAD, a bioactive extract from nutrient-rich sunflower sprouts, boosts NAMPT to increase the skin’s own NAD⁺ production, thereby restoring cellular energy and the skin’s own repair processes.
• Reduced autophagy: Cellaigie reactivates cellular cleansing processes to eliminate damaged proteins and accelerate skin cell renewal. Cellaigie targets mTOR, a key regulator of cellular metabolism, and puts skin cells into a renewal-oriented state similar to the benefits of cellular fasting. By reactivating autophagy signaling pathways, the elimination of damaged components is accelerated and efficient cell turnover is restored.
• Loss of collagen and elastin: PhytoCellTec exosomes stimulate the production of collagen III, XVI, and elastin in fibroblasts to increase skin firmness and tone. Exosomes are currently a hot topic in aesthetics. They are tiny vesicles produced by cells that act as messenger substances and enable the exchange of information between cells.
• Weakening of the skin barrier: Niacinamide, ectoine, low molecular weight hyaluronic acid, beta-glucan, betaine, and diglycerin strengthen the skin barrier, reduce transepidermal water loss, and alleviate inflammation. This is because the skin barrier becomes thinner and more sensitive with age, leading to dryness, irritation, increased water loss through the upper skin layer (TEWL), and increased sensitivity.

A facial serum based on longevity science

The Skinspan serum comes out of the sustainable, gray-matte dispenser in a milky white color, slightly thicker than conventional transparent serums. It has a neutral scent, more medicinal than cosmetic. The serum is vegan, paraben-free, cruelty-free, fragrance-free, and PEG-free. I apply two pumps to my still-damp skin on my face, neck, and décolleté in the morning and evening. Then I follow with my usual skincare routine.

After a month of consistent use, I notice that my skin is better hydrated and has a smoother texture. Dry patches and roughness have disappeared. Overall, it feels more supple. Everything indicates that my cell renewal and repair processes are already working better.

I will stick with it, because Avea promises more firmness and resilience in the second month. And for the third month: measurable improvements in structure and radiance. It is also recommended to combine it with the SkinSpan program, especially with the patented Collagen Activator. It is a nutritional supplement concept for stimulating the body’s own collagen synthesis. Maybe I’ll try that too. We’ll see!

Epigenetic skincare “SkinSpan Advanced Skin Serum” by Avea, 30 ml, $109